The primary criteria for the selection of appropriate compounds were the MICs and IC 50 s used for a quantification of effects. The natural compounds with activity close to the reference substances or showing MIC up to 32 µg ml ?1 , and IC 50 of anti-inflammatory effect up to 15 µM were considered as promising. When available, information about in vivo testing was included. Reviewed dual inhibitors can represent modern therapeutic approach, especially when the process of inflammation is followed by a secondary bacterial infection. Benefits of dual inhibitors are based on better compliance of patients, decreased number of side effects and extended spectrum of action.
CBD oil can be derived from both marijuana and hemp. Because hemp has only trace amounts of THC, oils derived from this variety are completely legal. Products based on marijuana, however, are only allowed for medical use under very specific restrictions in Maryland cannabis seeds.